Congratulations to Drs. Laura Colgin and Darrin Brager on their RO1 from the National Institute of Mental Health!
This award will provide more than 3 million dollars over a four year period to support their their research proposal “Investigating mechanisms underlying impaired social and spatial cognition in rodent models of Fragile X syndrome”.
Fragile X syndrome (FX) is associated with deficits in social and spatial behaviors, yet the neural mechanisms responsible for these impairments remain poorly understood. Hippocampal areas CA2 and CA1 are key brain regions for sociality and spatial memory, respectively. In this project, we aim to uncover neurophysiological disturbances in CA2 and CA1 that may underlie impaired social and spatial cognition in FX and may point toward new symptom-specific treatment targets.